Keep the Muscle

If you’ve started Ozempic, Wegovy, Mounjaro, or Zepbound — or you’re thinking about it — you’ve probably run into a specific, scary number: "up to 40% of the weight you lose will be muscle." Here’s the more accurate and, honestly, more useful way to think about it: The scale doesn’t tell you whether you’re losing weight well. GLP-1 medications can produce substantial weight loss. Some lean mass typically comes with that, the same way it does with almost any substantial weight loss, by any method. But lean mass is not the same thing as muscle, and losing body weight does not automatically mean losing strength.

— excerpt from the guide's introduction