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Fatiguing a muscle with an isolation exercise first, then immediately working it with a compound exercise.
In pre-exhaustion, a muscle group is trained to the point of fatigue in an isolated (body-part) exercise, then followed by a structural (major/compound) exercise. For example, leg extensions before squats.
This reverses the usual ordering principle (small muscle group trained before large muscle group) and is considered an advanced routine. A sample order is shown in the source as a program where single leg extension and hamstring curls precede squats — noted as "Pre-exhaustion, small muscle group trained before large muscle group (advanced routine)."
Educational content only — not medical advice. Always consult a qualified professional for individualized guidance, especially around injury, pregnancy, or medical conditions.